Introduction of High Pressure Homogenizer

High pressure homogenizer is a kind of machine used for super fine homogenizing. In many applications, such as food, pharmaceutical, cosmetic, biotechnology and chemical, particle size needs to be in the nanometer range. A high pressure homogenizer is ideally suited for this task. It is one of the most effective production equipment for the preparation of nanomaterials by applying nanotechnology process, and its application area is very wide.

SeFluid’s high pressure homogenizer consists mainly of a high-pressure homogenization chamber and a booster mechanism. The interior of the high pressure homogenizing chamber has a specially designed geometry. In the homogenizer chamber, high pressure is generated by one or more high pressure pumps. The high pressure is then released in a very narrow adjustable gap inside the homogenizing valve.

high pressure homogenizer - SeFluid



5.5-45 kw


500-5000 l/h


25 Mpa


SS304, SS316

Principle of High Pressure Homogenizer

Under the action of the booster mechanism, the high pressure solution passes rapidly through the high pressure homogenizer working chamber. After that, the raw material is simultaneously subjected to mechanical forces such as high speed shear, high frequency oscillation and convective impact. As a result, mechanical and chemical effects can induce changes in the physical, chemical and structural properties of the material macromolecules. Eventually, the material achieves the effect of homogenization.

Features of High Pressure Homogenizer


Sufficient flow rate, no changing to flow when pressure is high.


Super Fine particle size with micron Φ0.01-2 after procssing.


Low noise, crank arm transmission gear, high flow and double shaft dynamo.


Reliable sealing and no leak risk, easy disassembling and maintenance.


Conical valve surface contact for one-way valve, no leakage, steady pressure and sufficient flow.

Max. Pressure of High Pressure Homogenizer

In general, the higher the homogenization pressure, the better. First, the higher the homogenization pressure, the smaller and more uniform the particle size of the homogenized material will be. This makes the equipment more efficient, and the desired effect can be achieved with fewer cycles; secondly, the higher the homogenization pressure, the more kinds of materials can be processed. For example, some liquid emulsions require only 20,000 psi to homogenize to below 100 nm, while some suspensions containing higher density solid particles require at least 26,000 psi or more to process to the nanometer scale.

But at the same time, it should be noted that the higher the homogenization pressure, the greater the calorific value, and the high temperature will affect the homogenization effect of the material. Therefore, generally without cooling measures, 30000psi is the highest pressure for ultra-high pressure homogenization.

Test of High Pressure Homogenizing Quality

When the material processed by the high pressure homogenizer reaches the desired particle size, the particle size distribution should be centralized, and the particle size distribution should not be equivalent from tens of nanometers to several micrometers. Special attention should be paid to the content of large particles in the post-quality material. The large particle distribution in pharmaceutical emulsions is clearly defined in the pharmacopoeia of many countries.

For the effect of material homogenization, it is best to choose a suitable particle size analyzer for testing. For example, in the detection of emulsions in the pharmaceutical industry, the US Pharmacopoeia clearly stipulates that the Extinction method should be used to determine the distribution of large particle size materials in emulsions. Therefore, users in different industries should select the corresponding particle size analyzer for testing according to the standards of their respective industries.

Application of High Pressure Homogenizer

application of high pressure homogenizer 3 - SeFluid

pharmaceutical industry

Preparation of microemulsions, liposomes, suspensions and microcapsules.

bioengineering Industry | High Pressure Homogenizer | SeFluid

bioengineering Industry

Cell crushing, extraction and homogenization of intra and extracellular substances.

application of high pressure homogenizer 1 - SeFluid

food & beverage industry

Emulsification and homogenization for improving product stability.

application of high pressure homogenizer 4 - SeFluid

cosmetic & fine chemical Industry

Homogenization and dispersion of products for higher quality level.


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